In the United States, the cannabidiol drug Epidiolex was approved by the Food and Drug Administration in 2018 for treatment of two epilepsy disorders.[12] The side effects of long-term use of the drug include somnolence, decreased appetite, diarrhea, fatigue, malaise, weakness, and sleeping problems.[2] As of mid-2019 in the United States, CBD is a Schedule I controlled substance that is illegal for use in human foods, dietary supplements, other consumer products, or pet foods.[13][14]
The good news is that numerous states have enacted legislation that allows for the use of CBD. Just four states (Idaho, South Dakota, Nebraska, and Kansas) forbid any access to marijuana. Ten states and Washington, D.C., currently allow for both medical and recreational use of cannabis, including CBD products. The other 36 states allow for the use of medical cannabis in some form, though some of these relegate this to CBD oil only.
Cannabidiol is a chemical in the Cannabis sativa plant, also known as marijuana. Over 80 chemicals, known as cannabinoids, have been identified in the Cannabis sativa plant. While delta-9-tetrahydrocannabinol (THC) is the major active ingredient, cannabidiol makes up about 40% of cannabis extracts and has been studied for many different uses. According to the U.S. Food and Drug Administration (FDA), because cannabidiol has been studied as a new drug, products containing cannabidiol are not defined as dietary supplements. But there are still products labeled as dietary supplements on the market that contain cannabidiol. The amount of cannabidiol contained in these products is not always reported accurately on the product label.
Schizophrenia. Research on the use of cannabidiol for psychotic symptoms in people with schizophrenia is mixed. Some early research suggests that taking cannabidiol four times daily for 4 weeks improves psychotic symptoms and might be as effective as the antipsychotic medication amisulpride. But other early research suggests that taking cannabidiol for 14 days is not beneficial. The mixed results might be related to the cannabidiol dose used and duration of treatment.

Cannabis has been cultivated by humans, for a variety of purposes, since antiquity. So it comes as no surprise that there are several different species and even different varieties within the species, depending on the purpose the plants were bred for. Through artificial selection, different species of cannabis have different properties–some have been used for medicinal purposes, others as food, and others to create clothes, ropes, and other items.
Until relatively recently (1980s), scientists believed that CBD was a natural precursor to the formation of THC, and since THC was a strictly controlled substance back then (it still is), it only followed that CBD should be equally strictly regulated. However, CBD is actually unrelated to the chemical chain that results in THC. They share some characteristics but are created via different paths. Again, unlike THC, CBD is considered a legal cannabinoid and is safe to consume in any amount and concentration.
As we have also seen above, CBD is considered to have wider applications than THC. Since CBD has been much less studied than THC, scientists assume that there are many new applications of CBD that haven’t yet been discovered. On the other hand, THC’s applications are more or less completely explored by now due to all the research on medical marijuana over the past decade.
Nabiximols (brand name Sativex) is a patented medicine containing CBD and THC in equal proportions. The drug was approved by Health Canada in 2005 for prescription to treat central neuropathic pain in multiple sclerosis, and in 2007 for cancer related pain.[32] In New Zealand, Sativex is "approved for use as an add-on treatment for symptom improvement in people with moderate to severe spasticity due to multiple sclerosis who have not responded adequately to other anti-spasticity medication."[33]
Selective breeding of cannabis plants has expanded and diversified as commercial and therapeutic markets develop.[13] Some growers in the US succeeded in lowering the proportion of CBD-to-THC to accommodate customers who preferred varietals that were more mind-altering due to the higher THC and lower CBD content.[52] In the US, hemp is classified by the federal government as cannabis containing no more than 0.3% THC by dry weight. This classification was established in the 2018 Farm Bill and was refined to include hemp-sourced extracts, cannabinoids, and derivatives in the definition of hemp.[53]
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Until 2017, products containing cannabidiol marketed for medical purposes were classed as medicines by the UK regulatory body, the Medicines and Healthcare products Regulatory Agency (MHRA) and could not be marketed without regulatory approval for the medical claims.[69] As of 2018, cannabis oil is legal to possess, buy, and sell in the UK, providing the product does not contain more than 0.3% THC and is not advertised as providing a medicinal benefit.[70]
Parkinson’s disease. Some early research shows that taking cannabidiol daily for 4 weeks improves psychotic symptoms in people with Parkinson’s disease and psychosis. But taking a specific cannabis extract (Cannador) that contains THC and cannabidiol does not appear to improve involuntary muscle movements caused by the anti-Parkinson’s drug levodopa in people with Parkinson’s disease.
Parkinson’s disease. Some early research shows that taking cannabidiol daily for 4 weeks improves psychotic symptoms in people with Parkinson’s disease and psychosis. But taking a specific cannabis extract (Cannador) that contains THC and cannabidiol does not appear to improve involuntary muscle movements caused by the anti-Parkinson’s drug levodopa in people with Parkinson’s disease.
Prescription medicine (Schedule 4) for therapeutic use containing 2 per cent (2.0%) or less of other cannabinoids commonly found in cannabis (such as ∆9-THC). A schedule 4 drug under the SUSMP is Prescription Only Medicine, or Prescription Animal Remedy – Substances, the use or supply of which should be by or on the order of persons permitted by State or Territory legislation to prescribe and should be available from a pharmacist on prescription.[58]
More important than legality is understanding if CBD is safe for you. While studies are still ongoing about the long-term safety of CBD usage, most experts agree that it is easily tolerated by most adults with no significant side effects on mood, physiology, or the central nervous system. Many CBD products, including oils and tinctures, also allow you to customize your serving size, which can help you avoid or mitigate any potential side effects.
The 2014 Farm Bill[86] legalized the sale of "non-viable hemp material" grown within states participating in the Hemp Pilot Program.[53] This legislation defined hemp as cannabis containing less than 0.3% of THC delta-9, grown within the regulatory framework of the Hemp Pilot Program.[87] The 2018 United States farm bill allowed for interstate commerce of hemp derived products, though these products still fall under the purview of the FDA.[88][89]
CBD Isolate is the purest supplement available. It’s a 99% pure CBD supplement derived from hemp oil. Despite its concentration, CBD isolate effects are similar to other CBD concentrates, and it can be used in a variety of ways. It can be consumed itself, added to foods and beverages, or vaporized. You can also add it to other CBD products to increase their potency.
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